The museum houses exhibits on the Ais, who lived in the the Fort Pierce area at the time of Spanish exploration, include artifacts from the period and reproductions of sketches made at the time of European contact. The museum also presents a recreated early 20th-century Seminole encampment.

The Treasure Room features artifacts from the 1715 treasure fleet wrecks, a ship model, salvage diorama, and salvage inventory.

Information provided by Florida Department of State.